Welcome to our lab!
We study the molecular mechanisms underlying human disease and focus on cellular signaling networks. A particular emphasis is given to the discovery and development of new chemical tools for regulating protein kinases - key elements in signal transduction networks. We employ multidisciplinary research approaches from in vitro assays, computational analyses and animal models to identify new therapeutic targets, and to design bioactive agents as future therapies. We focus on neurodegenerative disorders and cancer.
Research Projects in Our Laboratory
Study the role of autophagy and lysosome network in neurodegenerative disorders.
Design bioactive molecules that function as substrate competitive inhibitors for protein kinases
Study evolutionary perspective of GSK-3 as a unique tool for novel drug design
Inhibition of GSK-3 ameliorates the pathogenesis of Huntington's disease
GSK-3 accelerates the accumulation of mutant huntingtin aggregates by suppressing the autophagy-lysosome pathway. Inhibition of GSK-3 clears brain-mutant huntingtin aggregates and improves motor and coordination ability in Huntington's diseases mice. Inhibition of GSK3 provides neuroprotection to the Huntington's brain by restoring declined expression levels of Sirt1