Welcome to our lab!
We study molecular mechanisms underlying human disease and focusing at cellular signaling networks. A particular emphasis is given to the discovery and development of new chemical tools for regulating protein kinases- key elements in signal transduction networks. We employ multidisciplinary research platforms from in vitro assays, computational analyses, and animal models to decipher signaling components that contribute to molecular pathogenesis, and to identify and design bioactive agents as future therapies. Our goal is to develop new therapeutics for diverse pathological disorders including diabetes, neurodegenerative disorders and cancer.
Research Projects in Our Laboratory
Development of systematic platform for development of protein kinase inhibitors
Design bioactive molecules that function as substrate competitive inhibitors for protein kinases
Study the role of autophagy and lysosome network in neurodegenerative disorders and cancer
Study evolutionary perspective of protein kinases as a unique tool for novel drug design
Inhibition of GSK-3 ameliorates the pathogenesis of Huntington's disease
GSK-3 accelerates the accumulation of mutant huntingtin aggregates by suppressing the autophagy-lysosome pathway. Inhibition of GSK-3 clears brain-mutant huntingtin aggregates and improves motor and coordination ability in Huntington's diseases mice. Inhibition of GSK3 provides neuroprotection to the Huntington's brain by restoring declined expression levels of Sirt1
Prof. Hagit Eldar-Finkelman, Ph.D.
Professor at the Department of Human Molecular Genetics & Biochemistry
Sara Melisa Arciniegas Ruiz - e-mail
Ido Rippin - e-mail
Vipin Kumar Singh
Shani Ben Shlomo
Wish to join us?
Open Positions for Post-doctoral Fellows: For a new grant-supported project in drug development and its implications in neurodegenerative diseases.We are looking for highly motivated individuals for a challenging project that combines basic and industry-oriented research.
We are currently seeking for highly motivated Ph.D and M.Sc students. For a new and innovative project in drug discovery and drug development: Implications in neurodegenerative disorders
30 Haim Levanon st., Ramat Aviv
Tel Aviv 69978