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Welcome to our lab!

We study molecular mechanisms underlying human disease and focusing at cellular signaling networks. A particular emphasis is given to the discovery and development of new chemical tools for regulating protein kinases- key elements in signal transduction networks. We employ multidisciplinary research platforms from in vitro assays, computational analyses, and animal models to decipher signaling components that contribute to molecular pathogenesis, and to identify and design bioactive agents as future therapies. Our goal is to develop new therapeutics for diverse pathological disorders including diabetes, neurodegenerative disorders and cancer. 

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Research Projects in Our Laboratory

  1. Development of systematic platform for development of protein kinase inhibitors

  2. Design bioactive molecules that function as substrate competitive inhibitors for protein kinases

  3. Study the role of autophagy and lysosome network in neurodegenerative disorders and cancer

  4. Study evolutionary perspective of protein kinases as a unique tool for novel drug design

Stack of Magazines

Latest Publications

Inhibition of GSK-3 ameliorates the pathogenesis of Huntington's disease

GSK-3 accelerates the accumulation of mutant huntingtin aggregates by suppressing the autophagy-lysosome pathway. Inhibition of GSK-3 clears brain-mutant huntingtin aggregates and improves motor and coordination ability in Huntington's diseases mice. Inhibition of GSK3 provides neuroprotection to the Huntington's brain by restoring declined expression levels of Sirt1

The Team

Prof. Hagit Eldar-Finkelman, Ph.D.

 

Professor at the Department of Human Molecular Genetics & Biochemistry

Lab Manager

Eva Berent - e-mail

Shirley Joseph 

Ekaterina Bondar 

Research Associate

Post-Doc Fellows

Sara Melisa Arciniegas Ruiz - e-mail

Lina Tsaadon-Alon

Inbar Azulai-Alfaguter 

Avital Licht-Murava

Lilach Vaks 

Ph.D Students

Ido Rippin - e-mail

Ilana Talior

Oksana Kaidanovich

Ronit Ilouz

Ziva Liberman

Racheli Karyo

Inbar Azulai-Alfaguter 

Avital Licht-Murava 

Moran Shapira 

Limor Avrahami 

Vipin Kumar Singh

M.Sc. Students

Anita Goren 

Hana Shpilt

Tania Trugman

Mor Zavaro

Meyrav Dayan 

Ammar Sarsor 

Noa Kirshenboim

Merav Yarkon

Oksana Kaidanovich

Ronit Ilouz

Shani Ben Shlomo

Ofra Kriger

Moran Shapira 

Hadar Sherfi

Ziva Liberman

Avital Licht-Murava 

Limor Avrahami 

Giora Volpert 

Maya Shaham-Kol

Itay Aloni

Reut Elya

Nastiz Paz

Rom Paz

Hadas Hodadov 

Contact Us

Wish to join us?

  • Open Positions for Post-doctoral Fellows: For a new grant-supported project in drug development and its implications in neurodegenerative diseases.We are looking for highly motivated individuals for a challenging project that combines basic and industry-oriented research.

  • We are currently seeking for highly motivated Ph.D and M.Sc students. For a new and innovative project in drug discovery and drug development: Implications in neurodegenerative disorders

email: heldar@tauex.tau.ac.il
+972-3-6405307

+972-3-6405308

30 Haim Levanon st., Ramat Aviv

Tel Aviv 69978

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